In-depth analysis of cell factories design and application

Cell factories have emerged as an efficient cell culture system in modern biopharmaceutical and vaccine production.

Cell factories have emerged as an efficient cell culture system in modern biopharmaceutical and vaccine production.
Materials and surface modifications:
Cell factories use polystyrene as the main material. This material is widely used because of its transparency, strength and plasticity. Polystyrene is non-toxic and performs well in cell culture. However, its hydrophobic surface properties pose challenges for cell attachment and growth. To optimize cell attachment and growth performance, the surface of cell factories is often hydrophilic. This process introduces hydrophilic functional groups that enable better cell attachment to the culture surface, thereby improving cell growth efficiency and culture quality.
Structural and Design Advantages:
The Cell Factory utilizes a multi-layer design that greatly saves space and improves culture efficiency. Common configurations include 1-layer, 2-layer, 5-layer, 10-layer, and 40-layer, with culture areas of 635 cm2, 1270 cm2, 3175 cm2, 6350 cm2, and 25400 cm2, respectively. This stacked design not only increases the amount of cells per unit area, but also makes the production process more compact and efficient.

In addition, the cell factories utilize a piping system for closed liquid transfer, reducing the risk of external contamination while increasing the safety and reliability of the production process. The closed nature of the liquid transfer ensures a pure culture environment and provides stable conditions for cell growth.
Wide range of applications:
Cell factories have a wide range of applications. They can be used for large-scale cultivation of desired viruses or cell lines, thereby increasing productivity and reducing costs. In the field of biopharmaceuticals, cell factories ensure high quality and large-scale production of drugs.
In conclusion, as an important tool for modern biomanufacturing, cell factories are having a significant impact on biopharmaceuticals and cellular therapies due to their unique materials, structural design and wide range of applications. As technology continues to advance and applications expand, cell factories will play an increasingly critical role in the future of biomanufacturing.